Preparation method of lenalidomide

The invention provides a preparation method of lenalidomide. The preparation method of the lenalidomide comprises the steps of preparing an intermediate 2-halogen methyl-3 methyl nitrobenzoate and anintermediate 3-amino piperidine-2,6-diketone, and preparing the lenalidomide by using the two interme...

Full description

Saved in:
Bibliographic Details
Main Author PENG WEI'EN
Format Patent
LanguageChinese
English
Published 05.11.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

Abstract The invention provides a preparation method of lenalidomide. The preparation method of the lenalidomide comprises the steps of preparing an intermediate 2-halogen methyl-3 methyl nitrobenzoate and anintermediate 3-amino piperidine-2,6-diketone, and preparing the lenalidomide by using the two intermediates. The preparation method of the lenalidomide is simple in steps, high in yield, low in cost,and beneficial to industrial production. 本发明提供了一种来那度胺的制备方法。所述来那度胺的制备方法包括制备中间体2-卤甲基-3硝基苯甲酸甲酯和中间体3-氨基哌啶-2,6-二酮的步骤，以及利用这两个中间体制备来那度胺的步骤。所述来那度胺的制备方法步骤简单，收率较高，成本较低，有利于工业化生产。
AbstractList The invention provides a preparation method of lenalidomide. The preparation method of the lenalidomide comprises the steps of preparing an intermediate 2-halogen methyl-3 methyl nitrobenzoate and anintermediate 3-amino piperidine-2,6-diketone, and preparing the lenalidomide by using the two intermediates. The preparation method of the lenalidomide is simple in steps, high in yield, low in cost,and beneficial to industrial production. 本发明提供了一种来那度胺的制备方法。所述来那度胺的制备方法包括制备中间体2-卤甲基-3硝基苯甲酸甲酯和中间体3-氨基哌啶-2,6-二酮的步骤，以及利用这两个中间体制备来那度胺的步骤。所述来那度胺的制备方法步骤简单，收率较高，成本较低，有利于工业化生产。
Author PENG WEI'EN
Author_xml – fullname: PENG WEI'EN
BookMark eNrjYmDJy89L5WRQCihKLUgsSizJzM9TyE0tychPUchPU8hJzUvMyUzJz81MSeVhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaGBiYG5hYG5o7GxKgBAJ-sJ-E
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
DocumentTitleAlternate 一种来那度胺的制备方法
ExternalDocumentID CN110407807A
GroupedDBID EVB
ID FETCH-epo_espacenet_CN110407807A3
IEDL.DBID EVB
IngestDate Fri Jul 19 15:40:18 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language Chinese
English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_CN110407807A3
Notes Application Number: CN201910530172
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191105&DB=EPODOC&CC=CN&NR=110407807A
ParticipantIDs epo_espacenet_CN110407807A
PublicationCentury 2000
PublicationDate 20191105
PublicationDateYYYYMMDD 2019-11-05
PublicationDate_xml – month: 11
  year: 2019
  text: 20191105
  day: 05
PublicationDecade 2010
PublicationYear 2019
RelatedCompanies GANSU TAISHENG CHEMICAL TECHNOLOGY CO., LTD
RelatedCompanies_xml – name: GANSU TAISHENG CHEMICAL TECHNOLOGY CO., LTD
Score 3.356383
Snippet The invention provides a preparation method of lenalidomide. The preparation method of the lenalidomide comprises the steps of preparing an intermediate...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title Preparation method of lenalidomide
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191105&DB=EPODOC&locale=&CC=CN&NR=110407807A
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSUk1NElKNkjUBU066ZqYJaboJiWZJOmmWQK7YqmgmSNL0AZnXz8zj1ATrwjTCCaGLNheGPA5oeXgwxGBOSoZmN9LwOV1AWIQywW8trJYPykTKJRv7xZi66IG7R0DOx_A9oKai5Ota4C_i7-zmrOzrbOfml-QLVAcNGNlYO7IzMAKbEabg3KDa5gTaFdKAXKV4ibIwBYANC2vRIiBqSpDmIHTGXbzmjADhy90whvIhOa9YhEGpYCiVMhB3fl5CpCLnxXy0xSAtQawKZ2Snwv0jSiDoptriLOHLtCyeLjP4p39EO4yFmNgAfb4UyUYFFKSU02TjZLMUhJB-0QNTBMtQNeXG5qkGqemgs57k2SQwm2OFD5JaQYuUCiBN9OZyjCwlBSVpsoCa9WSJDlwcAAAB-h6-Q
link.rule.ids 230,309,783,888,25576,76876
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSUk1NElKNkjUBU066ZqYJaboJiWZJOmmWQK7YqmgmSNL0AZnXz8zj1ATrwjTCCaGLNheGPA5oeXgwxGBOSoZmN9LwOV1AWIQywW8trJYPykTKJRv7xZi66IG7R0DOx_A9oKai5Ota4C_i7-zmrOzrbOfml-QLVAcNGNlYO7IzMAKbGKbg3KDa5gTaFdKAXKV4ibIwBYANC2vRIiBqSpDmIHTGXbzmjADhy90whvIhOa9YhEGpYCiVMhB3fl5CpCLnxXy0xSAtQawKZ2Snwv0jSiDoptriLOHLtCyeLjP4p39EO4yFmNgAfb4UyUYFFKSU02TjZLMUhJB-0QNTBMtQNeXG5qkGqemgs57k2SQwm2OFD5JeQZOjxBfn3gfTz9vaQYuUIiBN9aZyjCwlBSVpsoCa9iSJDlw0AAA9tB97A
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Preparation+method+of+lenalidomide&rft.inventor=PENG+WEI%27EN&rft.date=2019-11-05&rft.externalDBID=A&rft.externalDocID=CN110407807A