Preparation method of lenalidomide

The invention provides a preparation method of lenalidomide. The preparation method of the lenalidomide comprises the steps of preparing an intermediate 2-halogen methyl-3 methyl nitrobenzoate and anintermediate 3-amino piperidine-2,6-diketone, and preparing the lenalidomide by using the two interme...

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Bibliographic Details
Main Author PENG WEI'EN
Format Patent
LanguageChinese
English
Published 05.11.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides a preparation method of lenalidomide. The preparation method of the lenalidomide comprises the steps of preparing an intermediate 2-halogen methyl-3 methyl nitrobenzoate and anintermediate 3-amino piperidine-2,6-diketone, and preparing the lenalidomide by using the two intermediates. The preparation method of the lenalidomide is simple in steps, high in yield, low in cost,and beneficial to industrial production. 本发明提供了一种来那度胺的制备方法。所述来那度胺的制备方法包括制备中间体2-卤甲基-3硝基苯甲酸甲酯和中间体3-氨基哌啶-2,6-二酮的步骤，以及利用这两个中间体制备来那度胺的步骤。所述来那度胺的制备方法步骤简单，收率较高，成本较低，有利于工业化生产。
Bibliography:Application Number: CN201910530172