TOSYLACETATE BASED COMPOUNDS AND DERIVATIVES THEREOF AS PHGDH INHIBITORS

The present invention encompasses compounds of formula (I), wherein the groups R1 to R, A1 to A4 and n have the meanings given in the claims and specification, their use as inhibitors of PHGDH, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially...

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Bibliographic Details
Main Authors WEINSTABL HARALD, TREU MATTHIAS, ZAHN STEPHAN KARL, WELLENZOHN BERND, DAHMANN GEORG
Format Patent
LanguageChinese
English
Published 29.10.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention encompasses compounds of formula (I), wherein the groups R1 to R, A1 to A4 and n have the meanings given in the claims and specification, their use as inhibitors of PHGDH, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases. 本发明包括式(I)的化合物，其中基团R至R、A至A和n具有权利要求和说明书中给出的含义，它们作为PHGDH抑制剂的用途，含有这种化合物的药物组合物以及它们作为药剂、尤其是作为用于治疗和/或预防肿瘤疾病的用途。
Bibliography:Application Number: CN201880017556