DEVICES, METHODS, AND COMPOSITIONS USEFUL IN CRYO-PRESERVATION, STORAGE, TRANSPORT, AND APPLICATION OF THERAPEUTIC MAMMALIAN CELLS

• Main Authors: SILVERMAN LARA, DULATOV GALINA, TANDESKI TERRY, ERICKSON ISAAC
• Format: Patent
• Language: Chinese; English
• Published: 29.10.2019
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPIRITS; TRAPPING; VINEGAR; WINE

The disclosed compositions, methods, and devices are useful in freezing, storing, and administering therapeutic eukaryotic cells to a patient in need thereof. In many embodiments, the disclosed therapeutic cells are mammalian cells derived from human intervertebral disc tissue. The disclosed compositions, methods, and devices are able to maintain high viability and sterility of the therapeutic cells, and allow the cells to be administered to a patient directly from the freezing container without manipulation of the cells or transferring to a second container. 本发明所公开的组合物、方法和装置可用于将治疗性真核细胞冷冻、储存和施用于所需患者。在许多实施方式中，所公开的治疗细胞是源自人椎间盘组织的哺乳动物细胞。所公开的组合物、方法和装置能够保持治疗细胞的高活力和无菌性，并且允许细胞从冷冻容器取出而无需处理细胞或转移至第二容器直接给予患者。