Coxsackie B virus for treatment of tumors

• Main Authors: WANG WEI, YE XIANGZHONG, FU WENKUN, CHENG TONG, PAN DEQUAN, ZHANG JUN, XIA NINGSHAO
• Format: Patent
• Language: Chinese; English
• Published: 29.10.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to the field of viruses and the field of tumor therapy, in particular to coxsackie B virus 1 (CVB1) or a modified form thereof, or a nucleic acid molecule comprising a genomic sequence or a cDNA sequence comprising the CVB1 or the modified form thereof or comprising complementary sequences of the genomic sequence or the cDNA sequence, use for treatment of tumors in a subject(such as a person), and use for the preparation of a pharmaceutical composition for treatment of the tumors in the subject (such as a person). The invention further relates to a method for treatment of the tumors. The method comprises the step of applying the CVB1 or the modified form thereof, or the nucleic acid molecule comprising the genomic sequence or the cDNA sequence comprising the CVB1 orthe modified form thereof or comprising the complementary sequences of the genomic sequence or the cDNA sequence to the subject in need. 本发明涉及病毒领域和肿瘤治疗领域。具体而言，本发明涉及CVB1或其修饰形式，或包含CVB1或其修饰形式的基因组序列或cDNA序列，或所述基因组序列或cDNA序列的互补序列的核酸分