SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS

• Main Authors: JIANG YUTONG, ANDREWS STEVEN W, MCKENNEY MEGAN L, MORENO DAVID A, MCNULTY OREN T, BRANDHUBER BARBARA J, KOLAKOWSKI GABRIELLE R, MCFADDIN ELIZABETH A, HAAS JULIA, TANG TONY P, BLAKE JAMES F, REN LI, ARONOW SEAN, METCALF ANDREW T, COOK ADAM
• Format: Patent
• Language: Chinese; English
• Published: 25.10.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are compounds of the Formula I and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in thespecification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. 本文提供式I的化合物：和其立体异构体和药学上可接受的盐或溶剂合物，其中A、B、X、X、X、X、环D和E具有在说明书中给出的含义，其是RET激酶的抑制剂且适用于治疗和预防可用RET激酶抑制剂治疗的疾病，包含RET相关疾病和病症。