Piperidine AMPK agonist and medical application thereof

The invention discloses a piperidine compound with AMPK agonistic activity and a preparation method and medical application thereof. The structural formula of the compound, a pharmaceutically acceptable salt or ester or a prodrug or N-oxide or a solvate is shown in a formula (I). The compound with t...

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Main Authors ZHAO XING, YOU YANPING, DAI LIANG, LIU JUN, CHENG YALONG, YAO ZHIYING, QIN LUZHE, FENG ZHIQI, SUN HONGBIN, ZHANG XIANGYING, WANG PENGFEI, LIU SHENGJIE, WEN XIAO'AN, SUN GENG
Format Patent
LanguageChinese
English
Published 25.10.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a piperidine compound with AMPK agonistic activity and a preparation method and medical application thereof. The structural formula of the compound, a pharmaceutically acceptable salt or ester or a prodrug or N-oxide or a solvate is shown in a formula (I). The compound with the structure shown in the formula (I) possibly activates the AMPK signaling pathway by activating the adiponectin receptor, and the compound can be used for the preparation of a medicament for preventing or treating an AMPK-mediated disease. Please see the specification for the formula (I). 本发明公开了一种具有AMPK激动活性的哌啶类化合物及其制备方法和医药用途，其为结构式如式(I)所示的化合物、其药学上可接受的盐或酯或前药或N-氧化物或溶剂化物。本发明的结构如式(I)所示的化合物可能通过激活脂联素受体而激活AMPK信号通路，因而可用于制备预防或治疗AMPK介导的疾病的药物。
Bibliography:Application Number: CN201810345937