一类含磺酰基的链状环状二肽类衍生物及其制备方法

• Format: Patent
• Language: Chinese
• Published: 18.11.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

本发明涉及一类含磺酰基的链状环状二肽类衍生物及其制备方法，其所述的含磺酰基的链状环状二肽类衍生物的结构式为：其合成方法是以胺类化合物、普通醛类以及磺酰基异腈化合物在MOF-Cu的催化作用下，以甲醇或乙醇或水为溶剂于室温下发生三组分Ugi反应，待反应完全后，过滤出MOF-Cu，经洗涤，干燥以备重复使用，将滤液经减压脱去溶剂甲醇，残留物经过柱层析得到最终目标化合物。该类化合物以一种反应简单、操作简便且副产物少、选择性较好的制备新方法来选择性地合成了一类含磺酰基的链状环状双酰胺化合物。 The invention relates to a chained cyclic dipeptide derivative containing sulfonyl groups and a preparation method thereof. A structural formula of the chained cyclic dipeptide derivative containing the sulfonyl groups is shown as follows (please see the description for the formula), and a synthesis method includes the steps that amine compounds, common aldehydes and sulfonyl isonitrile compoundsare used for carrying out a three-component Ugi reaction at room temperature with methanol, ethanol or water as solvents under the catalytic action of MOF-Cu, and after the reaction is completed, theMOF-Cu is filtered out, washed and dried for reuse; and the filtrate is decompressed to remove the solvent methanol, and residues are subject to column chromatography to obtain the fi