T CELLS WITH INCREASED IMMUNOSUPPRESSION RESISTANCE

• Main Authors: LAUGEL BRUNO, SKIBBE KATHRIN
• Format: Patent
• Language: Chinese; English
• Published: 11.10.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

This invention relates to the treatment of cancer in an individual by administration of a population of modified T cells that express a recombinant cAMP phosphodiesterase (PDE) or a fragment thereof and an antigen receptor which binds specifically to cancer cells in the individual. Populations of modified T cells and methods of producing populations of modified T cells are provided, along with pharmaceutical compositions and methods of treatment. 本发明涉及通过施用表达重组cAMP磷酸二酯酶(PDE)或其片段和与个体中癌细胞特异性结合的抗原受体的修饰的T细胞群来治疗个体癌症。本发明提供了修饰的T细胞群和产生修饰的T细胞群的方法，以及药物组合物和治疗方法。