SUBSTITUTED IMIDAZO-QUINOLINES AS NLRP3 MODULATORS

• Main Authors: ROUSH WILLIAM R, O'MALLEY DANIEL, GLICK GARY, GHOSH SHOMIR, OLHAVA EDWARD JAMES
• Format: Patent
• Language: Chinese; English
• Published: 11.10.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that modulate (e.g., agonizes or partially agonizes) NLRP3 that are useful, e.g., for treating a condition, disease or disorder in which an increase in NLRP3 signaling may correct a deficiency in innate immune activity (e.g.,a condition, disease or disorder associated with an insufficient immune response) that contributes to the pathology and/or symptoms and/ or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same. 本公开内容的特征在于调节(例如激动或部分激动)NLRP3的化学实体(例如化合物或该化合物的药学上可接受的盐和/或水合物和/或共晶和/或药物组合)，所述化学实体适用于例如治疗NLRP3信号传导的增加可校正先天免疫活性的缺陷的病症、疾病或障碍(例如与免疫反应不足相关的病症、疾病或障碍)，该先天免疫活性的缺陷促进个体(例如人类)病症、疾病或障碍(例如癌症)的病理和/或症状和/或进展。本公开内容的特征亦在于组合物以及使用及制备其的其他方法。