Preparation method of PCL (polycaprolactone)/CNTs (carbon nanotubes) compound electrospun film

• Main Authors: LIU XIAOCHEN, WANG JUN, ZHANG JIN, QIAO ZIWEN, ZENG LIANGDAN
• Format: Patent
• Language: Chinese; English
• Published: 10.09.2019
• Subjects: BRAIDING; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; COTTON-WOOL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS,NON-WOVEN FABRICS; HUMAN NECESSITIES; HYGIENE; KNITTING; LACE-MAKING; MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARYMATERIAL; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OFARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES ORRIBBONS; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; NATURAL OR ARTIFICIAL THREADS OR FIBRES; NON-WOVEN FABRICS; SPINNING; TEXTILES; TRIMMINGS; WADDING

The invention discloses a PCL (polycaprolactone)/CNTs (carbon nanotubes) compound electrospun film with optimal fiber orientation for inducing nerve regeneration. The PCL/CNTs compound electrospun film has the characteristics of large specific surface area and high porosity, is very similar to an extracellular matrix, and can be used as a support for supporting regeneration of various cells into complete tissues. The introduction of CNTs can further enhance the electrical activity of the composite support, so that the repair efficiency of nervous tissues is further improved under the action ofelectrical stimulation. The obtained PCL/CNTs compound electrospun film with the optimal fiber orientation lays a solid theoretical foundation for nerve defect repair in nervous tissue engineering, the process is simple, convenient, and easy to operate, and popularization and application are facilitated. 本发明公开了一种用于诱导神经再生的具有最佳纤维取向的PCL/CNTs复合静电纺丝膜，其具有大比表面积、高孔隙率的特点，与细胞外基质极为相似，可作为支撑各类细胞再生为完整组织的支架。CNTs的引入可进一步加强复合支架的电活性，从而在电刺激