Linezolid preparation method and linezolid refining method

• Main Authors: YIN DAHENG, LI WEI, HUANG YONGLI
• Format: Patent
• Language: Chinese; English
• Published: 03.09.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention provides a linezolid preparation method, which comprises: hydrogenation reduction, amino protection and reduction reaction. The invention further provides a linezolid refining method, which comprises: purifying, refining, crystal transformation, impurity removal and other processes. According to the present invention, the reaction of the linezolid synthesis process is simple, the reagent used in the reaction is safe and non-toxic, the reaction yield is high, and the purification process of the refining method is simple, and does not require complicated chromatographic purification; and the linezolid preparation method and the refining method are suitable for large-scale industrial production. 本发明提供了一种利奈唑胺的制备方法，包括如下步骤：氢化还原、氨基保护和还原反应。本发明还提供了一种利奈唑胺的精制方法，包括纯化、精制、转晶、除杂等过程。本发明的利奈唑胺合成工艺反应简单，反应中使用的试剂安全无毒，反应收率高，且本发明的精制方法纯化过程简单，无需使用冗杂的层析纯化，本发明的利奈唑胺的制备方法及精制方法均有利于大规模的工业化生产。