Medicine-polymer conjugate having high affinity on cryptococcus neoformans as well as preparation method and application thereof

• Main Authors: ZHOU LIYA, LUO YONGHUANG, LUO LEI
• Format: Patent
• Language: Chinese; English
• Published: 30.08.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a medicine-polymer conjugate having high affinity on cryptococcus neoformans as well as a preparation method and application thereof, and belongs to the field of polymers of pharmaceutical preparations. According to the medicine-polymer conjugate disclosed by the invention, amphotericin B is modified on the surfaces of polylactic acid-poly lactic-co-glycolic acid-polyethyleneglycol-N and hydroxysuccinimide, and a structure of the medicine-polymer conjugate is shown in a general formula I. The medicine-polymer conjugate disclosed by the invention has the high affinity on the cryptococcus neoformans, and has high biocompatibility and biodegradability. After the medicine-polymer conjugate is mixed with the polylactic acid-poly lactic-co-glycolic acid-polyethyleneglycol to obtain a mixture, the mixture covers the amphotericin B to form nano-particles; and moreover, for fungal infection, the medicine-polymer conjugate has a good treatment effect on cryptococcus neoformans infection in fung