Lipid formulated compositions and methods for inhibiting expression of EG5 and VEGF genes

• Main Authors: VAISHNAW AKSHAY, GOLLOB JARED, GAMBA-VITALO CHRISTINA, SAH DINAH WEN-YEE
• Format: Patent
• Language: Chinese; English
• Published: 16.08.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention relates to compositions containing double- stranded ribonucleic acid (dsRNA) in a liquid particle formulation, methods of using the compositions to inhibit the expression of the Eg5/KSPand VEGF, and methods of using the compositions to treat pathological processes mediated by Eg5/KSP and VEGF expression, such as endometrial cancer. 本发明涉及在液体颗粒制剂中含有双链核糖核酸(dsRNA)的组合物，利用该组合物抑制Eg5/KSP和VEGF的表达的方法，以及利用该组合物治疗由Eg5/KSP和VEGF表达介导的病理过程例如子宫内膜癌的方法。