Synthesis method of N-fatty acyl glutamic acid alkali metal salt

• Main Authors: XIONG YAQIN, LIU AIJU, CAO LIDAN, LIU KUNMING, LUO JUN, YAN ZHIPING
• Format: Patent
• Language: Chinese; English
• Published: 13.08.2019
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention aims at solving the technical problem that during synthesis of N-fatty acyl glutamic acid salt, when a solvent contains water, hydrolysis of fatty acyl chloride is severe. According to the technical scheme, a synthesis method of N-fatty acyl glutamic acid alkali metal salt comprises the step that an alkali mixture 1 with glutamic acid alkali metal salt, an amidation reaction additiveand a solvent is obtained in a reactor; the amidation reaction additive comprises N-fatty acyl glutamic acid alkali metal salt; the solvent comprises water; through stirring, the fatty acyl chlorideis added into the reactor, the fatty acyl chloride and the glutamic acid alkali metal salt react to generate the N-fatty acyl glutamic acid alkali metal salt in the reactor, and the pH of contents ofthe reactor keeps alkali in the reaction process. 本发明的目的是解决N-脂肪酰谷氨酸盐合成中当溶剂包括水时，脂肪酰氯水解严重的的技术问题，技术方案是：N-脂肪酰谷氨酸碱金属盐的合成方法，包括：(1)使反应器获得含谷氨酸碱金属盐、酰胺化反应助剂和溶剂的碱性混合物1；所述酰胺化反应助剂包括N-脂肪酰谷氨酸碱金属盐；所述溶剂包括水；搅拌下，将脂肪酰氯加到反应器中，在反应器中脂肪酰氯与谷氨酸碱金属盐反应生成N