Absorbable starch microsphere hemostatic powder with antibacterial activity and application thereof

• Main Authors: YUE YANG, GAO YIKUN, WANG SILING, ZHANG JINGHAI
• Format: Patent
• Language: Chinese; English
• Published: 13.08.2019
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses starch microsphere hemostatic powder with antibacterial activity and application thereof. The preparation method of the hemostatic powder comprises the following steps of adopting soluble starch as a raw material and sodium trimetaphosphate as a crosslinking agent for preparing starch microspheres with a three-dimensional network structure by means of a reverse emulsification crosslinking approach; adding the prepared starch microspheres into a lysozyme solution to obtain the lysozyme-loaded antibacterial starch microsphere hemostatic powder. The preparation method is simple, and the prepared lysozyme-loaded antibacterial starch microsphere hemostatic powder has excellent hemostatic performance, high bacteriostatic activity and high biocompatibility and can be degraded and absorbed by the human body. 本发明公开了一种具有抗菌活性的淀粉微球止血粉及其应用。所述止血粉制备方法包括以下步骤：以可溶性淀粉为原料，三偏磷酸钠为交联剂，采用反向乳化交联的方法制备具有三维网状结构的淀粉微球；将制得的淀粉微球加入到溶菌酶溶液中，得到负载溶菌酶的抗菌淀粉微球止血粉。本发明制备方法简单，所制得的负载溶菌酶的抗菌淀粉微球止血粉止血性能优良，具有良好的抑菌活性，生物相容性好，可被人体降解吸收。