NOVEL COMPOUND AND PHARMACEUTICALLY-ACCEPTABLE SALT THEREOF

• Main Authors: YAMAKAWA TAKERU, ISSHIKI SATOSHI, TABATA YUJI, MATSUHIRA TAKASHI, OUCHI SHOHEI, WAKIYAMA YOSHINARI, ISHIDA NATSUKI, TAMURA KEIJI
• Format: Patent
• Language: Chinese; English
• Published: 09.08.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided is a compound represented by general formula (1) or a pharmaceutically-acceptable salt thereof. In formula (1), R1 and R2 may be the same or different from each other, and each represents a hydrogen atom, a halogen atom, a hydroxy group, a carboxy group, a cyano group, or an optionally-substituted C1-6 alkyl group or the like; R3 represents a hydrogen atom; R4 represents an optionally-substituted 4- to 10-membered monocyclic heterocyclic group containing 1-4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by -CH2-, -CH2-CH2-, -CH2-CH2-CH2-, or -CH2-O-CH2-; and Z represents a hydrogen atom or a hydroxy group. 本发明涉及一种下述通式(1)所表示的化合物或其药理学上所容许的盐。[式(1)中，R及R可以相同也可以不同，各自表示氢原子、卤原子、羟基、羧基、氰基、可经取代的C烷基等；R表示氢原子；R表示可经取代的包含选自氧原子、氮原子及硫原子中1～4个杂原子的4～10元的单环式杂环基；X表示下述式：-CH-、-CH-CH-、-CH-CH-CH-、或-CH-O-CH-所表示的基；Z表示氢原子或羟基]。