COMBINATION THERAPY WITH TARGETED 4-1BB (CD137) AGONISTS
The present application relates to combination therapies employing tumor targeted anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists, in particular 4-1BBL trimer containing antigen binding molecules, the use of these combination therapies for the treatment of cancer and methods of using the c...
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Main Authors | , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
02.08.2019
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Subjects | |
Online Access | Get full text |
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Summary: | The present application relates to combination therapies employing tumor targeted anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists, in particular 4-1BBL trimer containing antigen binding molecules, the use of these combination therapies for the treatment of cancer and methods of using the combination therapies. The trimer CEA-4-1BBL (Figure IB) provides the highest tumor regression when combined with CEA CD3 TCB (See table 18).
本申请涉及采用肿瘤靶向性抗CD3双特异性抗体和4-1BB(CD137)激动剂,特别是含有4-1BBL三聚体的抗原结合分子的组合疗法,这些组合疗法用于治疗癌症的用途和使用该组合疗法的方法。三聚体CEA-4-1BBL(图1B)在与CEA CD3 TCB组合时提供最高肿瘤消退(见表18)。 |
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Bibliography: | Application Number: CN201780078076 |