BICYCLIC NITROGENATED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

• Main Authors: SUGIYAMA SHUICHI, OGAWA TOMOYUKI, KOJIMA EIICHI, KAI HIROYUKI, MASUDA KOJI, YAMADA TORU, KOBAYASHI NAOTAKE
• Format: Patent
• Language: Chinese; English
• Published: 30.07.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are: a novel compound having a P2X7 receptor inhibitory activity; and a pharmaceutical composition having a P2X7 receptor inhibitory activity. A compound represented by formula (I) (wherein Z1 represents C(R4) or the like; R4 represents a hydrogen atom or the like; Z2 represents C(R5a)(R5a') or the like; a broken line represents the presence or absence of a bond, wherein, when the brokenline represents the presence of a bond, R5a' is absent; R5a and R5a' independently represent a hydrogen atom or the like; the ring Q represents a substituted or unsubstituted 5-membered non-aromatic heterocyclic ring or the like; Y1 represents O or the like; R2a represents a group represented by the formula -(C(R2a')(R2b'))n-R1; R2b represents a hydrogen atom or the like; R2a' and R2b' independently represent a hydrogen atom or the like; R1 represents a substituted or unsubstituted aromatic carbocyclic group or the like; X represents N(R7a) or the like; R7a represents a hydrogen atom or the like; R3 represents a subst