Compositions and methods for modulating HBV and TTR expression

• Main Authors: SETH PUNIT P, PRAKASH THAZHA P, SWAYZE ERIC E
• Format: Patent
• Language: Chinese; English
• Published: 30.07.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention provides compositions and methods for modulating HBV and TTR expression. Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compoundsare conjugated to N-acetylgalactosamine. 本文提供了用于调节HBV和TTR表达的组合物和方法。本文还提供了具有缀合物基团的低聚化合物。在某些实施方案中，所述低聚化合物缀合至N-乙酰基半乳糖胺。