Synthetic method of nitrendipine

The invention relates to a synthetic method of nitrendipine. The synthetic method comprises the following steps that a reactant is subjected to a heating reaction in a reactive solvent to synthesize the nitrendipine; cooling is carried out after the reaction, the nitrendipine is filtered and dried,...

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Bibliographic Details
Main Authors ZANG XIAOMING, ZHAO KAI, TENG YINGXIN
Format Patent
LanguageChinese
English
Published 30.07.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a synthetic method of nitrendipine. The synthetic method comprises the following steps that a reactant is subjected to a heating reaction in a reactive solvent to synthesize the nitrendipine; cooling is carried out after the reaction, the nitrendipine is filtered and dried, and the reactive solvent is recovered, wherein the reactive solvent is acetonitrile. The synthetic method of the nitrendipine has the advantages that the reactive solvent nitrendipine free of an esterification reaction with the product is utilized, thereby avoiding the generation of impurities in the synthetic process, and improving the product purity of the synthetic reaction; the impurities generated during the reaction are dissolved in the reactive solvent, the nitrendipine is precipitated through cooling, and the impurities cannot be precipitated, thereby playing a role of purifying the synthetic nitrendipine; the reactive solvent nitrendipine can be purified through various methods, andthe reactive solvent nit
Bibliography:Application Number: CN201910492828