TRANS-ILLUMINATION IMAGING WITH AN ARRAY OF LIGHT SOURCES

A method and system for trans-illumination imaging are disclosed. In an exemplary method, a sample is irradiated in a well. The sample may include biological cells and a liquid or semi-solid medium that forms a meniscus. The step of irradiating may be performed with an array of light sources generat...

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Bibliographic Details
Main Author CHAN MATTHEW
Format Patent
LanguageChinese
English
Published 26.07.2019
Subjects
DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MEDICAL OR VETERINARY SCIENCE
SURGERY
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Summary:A method and system for trans-illumination imaging are disclosed. In an exemplary method, a sample is irradiated in a well. The sample may include biological cells and a liquid or semi-solid medium that forms a meniscus. The step of irradiating may be performed with an array of light sources generating light of respective light beams that are incident on the meniscus at different orientations fromone another. One or more images may be detected. A proportional contribution of light from two or more subsets of the light sources to the one or more images may be controlled by differential energization of the two or more subsets relative to one another to compensate for refraction by the meniscus and improve contrast. 本发明公开一种用于透射照明成像的方法和系统。在示例性方法中，在井中辐照样品。样品可以包括生物细胞和形成弯月面的液体或半固体培养基。辐照步骤可以利用光源阵列进行，光源产生以彼此不同的取向入射到弯月面上的各个光束的光。可以检测一个或多个图像。可以通过光源的两个或更多子组的相对于彼此的差别激励，来控制来自两个或更多子组的光对一个或多个图像的比例贡献，以补偿由弯月面产生的折射并改善对比度。
Bibliography:Application Number: CN201780076583