Formulations for enteric delivery of therapeutic agents

• Main Authors: NELLAIAPPAN KALIAPPANADAR, JAVERI INDU
• Format: Patent
• Language: Chinese; English
• Published: 23.07.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention provides formulations containing pH-sensitive nanoparticles for the enteric delivery of therapeutic agents. The nanoparticles include a pH-sensitive polymer that protects the therapeuticagent against degradation in the stomach and allows it to be released in the small intestine or colon. The nanoparticle formulation is particularly effective at protecting sensitive biotherapeutic agents from degradation when administered orally, and makes it possible to avoid administration of such agents by injection. The invention provides methods for producing the formulations, as well as methods of treating diseases employing the formulations. 本发明提供含有pH敏感性纳米粒的制剂，其用于治疗剂的肠道递送。所述纳米粒包含pH敏感性聚合物，其保护所述治疗剂免于在胃中被降解，并允许其在小肠或结肠中释放。所述纳米粒制剂在口服给药时特别有效地保护敏感性生物治疗剂免于降解，并且可以避免这些药剂通过注射给药。本发明还提供用于制备所述制剂的方法，以及使用所述制剂治疗疾病的方法。