PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES

• Main Authors: DUGAN BENJAMIN J, CARSWELL EMMA L, EKWURU CHUKUEMEKA TENNYSON, MONCK NATHANIEL J T, ELUSTONDO FRED, OTT GREGORY R, COCHI ANNE, SIDHU GURWINDER, LEROUX FREDERIC GEORGES MARIE, FOWLER KATHERINE M, TREMAYNE NEIL, ROFFEY JONATHAN R, CHARLES MARK DAVID
• Format: Patent
• Language: Chinese; English
• Published: 19.07.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: (Formula (I)) wherein X,R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated. 本发明涉及用作细胞分裂周期7(Cdc7)激酶活性的抑制剂的式I化合物及其盐和溶剂化物：其中X、R、R和n各自如本文所定义。本发明还涉及用于制备这些化合物的方法，涉及包含这些化合物的药物组合物，并且涉及这些化合物在治疗增殖性障碍诸如癌症以及牵涉Cdc7激酶活性的其他疾病或病症中的用途。