Refining method for 7-ketolithocholic acid

• Main Authors: MA XINCHENG, ZHANG ZONGLEI, DUAN CHONGGANG, ZHAO SITAI, ZHANG NING, FENG GUANGLING, FU BINGYUE, LIU KUIKUI, XIAN JING
• Format: Patent
• Language: Chinese; English
• Published: 12.07.2019
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; STEROIDS

The invention discloses a refining method for 7-ketolithocholic acid. The refining method comprises the following steps that a crude 7-ketolithocholic acid product and alcohol react under acid catalysis to form ester, a crude 7-ketolithocholic acid ester product is obtained, refined in a mixed solvent and hydrolyzed under the alkaline condition, and the refined 7-ketolithocholic acid product is obtained. The refining method is mild in reaction condition and simple in operation, the reagents used in the method are low in cost and easy to obtain, the cost is low, the purifying effect is obvious,and the method is suitable for industrial production. 本发明公开了一种7-酮石胆酸的精制方法，其包括以下步骤：7-酮石胆酸粗品先在酸催化下与醇成酯，得到的7-酮石胆酸酯粗品在混合溶剂中精制后，再在碱性条件下水解，得到7-酮石胆酸精制品。本发明的精制方法反应条件温和、操作简单、所用试剂廉价易得、成本较低、纯化效果明显，适合工业化生产。