SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-kB PATHWAYS

• Main Authors: WILLENBROCK MICHAEL, SCHEIDEREIT CLAUS, LINDEMANN PETER, RADETZKI SILKE, VON KRIES JENS PETER, NAZARE MARC
• Format: Patent
• Language: Chinese; English
• Published: 02.07.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to chemical compounds and their use as a medicament in the treatment of a disease associated with genotoxic stress-induced IKK/NF-kappaB(NF-kappaB) activation, preferably in thetreatment of a subject suffering from cancer exhibiting genotoxic stress-induced IKK/NF-kappaB activation. The invention further relates to a pharmaceutical composition comprising a compound of the invention for the treatment of a subject afflicted by a disease associated with genotoxic stress-induced IKK/NF-kappaB activation. 本发明涉及化学化合物及其作为治疗与基因毒性应激诱导性IKK/NF-κB(NF-κB)活化相关的疾病的药物的用途，优选治疗患有表现出基因毒性应激诱导性IKK/NF-κB活化的癌症的受试者的药物的用途。本发明进一步涉及包含本发明化合物的药物组合物，用于治疗患有与基因毒性应激诱导性IKK/NF-κB活化相关的疾病的受试者。