IMMOLATIVE CELL-PENETRATING COMPLEXES FOR NUCLEIC ACID DELIVERY

• Main Authors: NEAR KATHERINE, VARGAS JESSICA R, WAYMOUTH ROBERT M, BLAKE TIM R, LEVY RONALD, BENNER NANCY, HAABETH OLE AUDUN WERNER, WENDER PAUL, MCKINLAY COLIN
• Format: Patent
• Language: Chinese; English
• Published: 02.07.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo. 本文尤其提供了用于将包括核酸的治疗剂、诊断剂和成像剂递送至细胞中的复合物、组合物和方法。所述复合物、组合物和方法可以促进对寡核苷酸和聚阴离子货物的复合、保护，向体外和体内的靶细胞、组织和器官中的递送和释放。