Long-acting glucagon-like peptide-1(GLP-1) analogue and application thereof

• Main Authors: BI XINZHOU, LIU CHUNXIA, SUN LIDAN, QIAN HAI, CAI XINGGUANG, DAI YUXUAN, HUANG WENLONG
• Format: Patent
• Language: Chinese; English
• Published: 28.06.2019
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a long-acting glucagon-like peptide-1(GLP-1) analogue and a synthetic method thereof. GLP-1 is transformed to obtain the GLP-1 analogue with longer pharmacological action time, the combination of a conjugate and serum albumin can be increased, the action time of a peptide chain is prolonged, rapid filtration and enzyme metabolism inactivation of the kidney can be avoided,and therefore, the half-life period and in-vivo hypoglycemic action time of the compound are significantly prolonged. 本发明涉及一类长效化胰高血糖素样肽-1(GLP-1)类似物及其合成方法。通过对GLP-1进行改造得到具有更长药理作用时间的GLP-1类似物，可增加缀合物与血清白蛋白的结合，延长肽链的作用时间，可避免肾脏的快速滤过和酶代谢失活，因而该类化合物的半衰期及体内降糖作用时间显著延长。