Apixaban structural analogue and preparation method thereof

The invention provides apixaban structural analogue ethyl 1-(4-amino)-7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl]-4, 5, 6, 7-tetrahydro-1H-pyrazole [3, 4-c] pyridine -3-carboxylate (I) and a preparationmethod thereof. According to a preparation method of the apixaban structural analogue, a synthetic ro...

Full description

Saved in:
Bibliographic Details
Main Author CAI LIANHUI
Format Patent
LanguageChinese
English
Published 18.06.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:The invention provides apixaban structural analogue ethyl 1-(4-amino)-7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl]-4, 5, 6, 7-tetrahydro-1H-pyrazole [3, 4-c] pyridine -3-carboxylate (I) and a preparationmethod thereof. According to a preparation method of the apixaban structural analogue, a synthetic route is as shown in specification. 本发明提供了一种阿哌沙班结构类似物1-(4-氨基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑[3,4-c]吡啶-3-甲酸乙酯(I)及其制备方法，合成路线如下：
Bibliography:Application Number: CN201910253772