Substituted hydroxystilbenes and their therapeutic applications

• Main Authors: LYLE MICHAEL PATRICK ALLEN, TANG LIREN, GUO TAO, ZHANG JUNLING
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2019
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides substituted hydroxystilbenes compounds of the general formula I that inhibit the activities of numerous of protein kinases involving the signaling of inflammatory cytokines, therefore, the compounds can be used for treating cancers, autoimmune diseases and inflammatory diseases. 本发明公开了通式I的取代的羟基均二苯乙烯化合物，所述化合物抑制许多蛋白激酶在炎性细胞因子的信号传导方面的活性，因此，所述化合物可用于治疗癌症、自身免疫疾病和炎性疾病。