Biomedical degradable double-layer stent for nerve repair and preparation method thereof

• Main Authors: WANG JUN, ZHANG JIN, QIAO ZIWEN, ZENG LIANGDAN
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2019
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OFARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES ORRIBBONS; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING; TEXTILES

The invention relates to a biomedical degradable double-layer stent for nerve repair and a preparation method thereof. The preparation method comprises first dissolving a polyester material in an organic solvent to obtain a polyester polymer solution; performing electrospinning to obtain an electrospinning fiber membrane; drying the electrospinning fiber membrane to obtain a fiber layer of a biodegradable double-layer stent; dissolving a polyvinyl alcohol material in deionized water, adding glycerin and sodium chloride in the heating, stirring and dissolving process, and obtaining a PVA/GI/NaCl polymer solution by ultrasonic processing; adding the PVA/GI/NaCl polymer solution into a glass die, laying the fiber layer on the surface of the solution, standing, freezing and thawing twice, to obtain hydrogel, and removing salt by washing to obtain the biomedical degradable double-layer stent for nerve repair. The biomedical degradable double-layer stent has excellent mechanical properties,controllable degradation