Antitumor composition

• Main Authors: HU XIANDE, LIAO NIANSHENG, LI YUANFANG
• Format: Patent
• Language: Chinese; English
• Published: 07.06.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of pharmaceutical chemistry, and discloses an antitumor composition. The antitumor composition contains medicine active components and medically acceptable auxiliarymaterials, wherein the medicine active components are a prodrug derivative of Ubernimex Bestatin shown as formula (I) or an optical isomerism system, a diastereomer, despinner MIZRUEW and pharmaceutically acceptable salt thereof. According to the antitumor composition, the residence time of medicines in bodies can be prolonged, the pharmacokinetics nature of the medicines can be improved, the biological availability of the medicines can be improved, and good antitumous effects can be achieved. 本发明涉及药物化学领域，公开了一种抗肿瘤药物组合物。该抗肿瘤药物组合物含有药物活性组分和药学上可接受的辅料，所述药物活性组分为式(I)所示的乌苯美司的前药衍生物或其光学异构体、非对映异构体、消旋体混合物及其药学上可接受的盐。本发明所述的抗肿瘤药物组合物可以延长药物在体内的滞留时间，改善药物的药代动力学性质，提高药物的生物利用度，从而达到更好的抗肿瘤效果。