TAT -CDKL5 FUSION PROTEINS, COMPOSITIONS, FORMULATIONS, AND USE THEREOF

• Main Authors: CLARK SEAN, LACCONE FRANCO, CIANI ELISABETTA
• Format: Patent
• Language: Chinese; English
• Published: 04.06.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Disclosed herein are compositions and formulations containing a TAT[kappa]-CDKL5 fusion protein. Also disclosed are methods of producing a TAT[kappa]-CDKL5 fusion protein from vectors containing a TAT[kappa]-CDKL5 cDNA and methods of transducer cells with the vectors containing a TAT[kappa]-CDKL5 cDNA and the TAT[kappa]-CDKL5 fusion protein. Also disclosed are uses of TAT[kappa]-CDKL5 fusion proteins for treating CDKL5 deficiencies by systemic or intravenous administration of the fusion proteins. 在此披露了含有TATκ-CDKL5融合蛋白的组合物和配制品。还披露了由含有TATκ-CDKL5 cDNA的载体产生TATκ-CDKL5融合蛋白的方法以及使用含有TATκ-CDKL5 cDNA的这些载体和该TATκ-CDKL5融合蛋白转导细胞的方法。还披露了TATκ-CDKL5融合蛋白用于治疗CDKL5缺陷的用途，该用途通过全身给予或静脉内给予该融合蛋白来实现。