Method for preparing key Sedacryptine intermediate beta-aminoketone

• Main Authors: ZHOU ZHU, SUN XUN, LIU YIWEN, WEI BANGGUO, SI CHANGMEI, NIE XIAODI, LIN GUOQIANG
• Format: Patent
• Language: Chinese; English
• Published: 04.06.2019
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the technical field of chemical synthesis, and relates to a method for preparing a key Sedacryptine intermediate beta-aminoketone. The method adopting a one-pot synthesis process to prepare the beta-aminoketone has the advantages of simplicity, wide substrate application, simplicity in operation, concise route and high yield; all reagents used in the method are common reagents, so the preparation cost of chiral beta-aminoketone is significantly reduced, and the beta-aminoketone can be prepared massively; and the prepared intermediate beta-aminoketone can be simply converted into the alkaloid Sedacryptine. 本发明属化学合成技术领域，涉及一种制备Sedacryptine的关键中间体β-氨基酮的方法。本发明所述的β-氨基酮采用一锅合成法制备，方法简便，底物应用广泛，操作简单，路线简洁，收率较高，所用的试剂均为常用试剂。本发明的技术路线制备手性β-氨基酮成本显著降低，可完成大量制备；合成制得的中间体β-氨基酮再经简单转化即可得到生物碱Sedacryptine。