Method for preparing lactone compounds

• Main Authors: LI HAORAN, LIANG CHENG, YUAN HAORAN, WANG LINGYAO, LI JINGBO
• Format: Patent
• Language: Chinese; English
• Published: 04.06.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a method for preparing lactone compounds. Cyclic ketone compounds are used as a raw material, a certain amount of an aldehyde assistant is added, and a reaction is carried outin an oxygen-containing atmosphere with cyclic organic nitroxide radical as a catalyst. The method for preparing lactone compounds under a metal-free catalytic oxidation condition has the advantages of mild conditions, high safety, high selectivity, great reduction of the use amount of the aldehyde assistant, improvement of the efficiency and range of the aldehyde assistant, and obtaining of the lactone compounds at a high yield. 本发明公开了一种制备内酯类化合物的方法，以环酮类化合物为原料，在含氧气氛下，以环状有机氮氧自由基为催化剂，加入一定量的醛类助剂进行反应。本发明公开了一种条件温和、安全性高、选择性高的无金属催化氧化的制备方法，大大降低醛类助剂的用量，提高醛类助剂的效率及范围，并可高收率地获得内酯类化合物。