COMPOUNDS AND METHODS OF PROMOTING MYELINATION

• Main Authors: ALLIMUTHU DHARMARAJA, HUBLER ZITA, ADAMS DREW, ELITT MATTHEW, TESAR PAUL
• Format: Patent
• Language: Chinese; English
• Published: 21.05.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of anagent that enhances and/or induces accumulation of delta8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells. 本申请涉及通过增强其存活和/或成熟促进少突胶质细胞从少突胶质细胞前体细胞产生的方法，包括向细胞给药有效量的增强和/或诱导少突胶质细胞前体细胞中胆固醇生物合成途径的Δ8,9-不饱和甾醇中间体的累积的试剂。