Culture method to obtain and maintain pure or enriched population of mammalian neural stem cells and/or neural progenitor cells

The invention provides an isolated expandable human neural stem or progenitor cell, wherein the cell is a progenitor cell or stem cell, maintains its capability to differentiate into neurons, astrocytes, and oligodendrocytes, maintains its ability to differentiate into oligodendrocyte lineage cells...

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Bibliographic Details
Main Author KIDO TSUNEO
Format Patent
LanguageChinese
English
Published 14.05.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention provides an isolated expandable human neural stem or progenitor cell, wherein the cell is a progenitor cell or stem cell, maintains its capability to differentiate into neurons, astrocytes, and oligodendrocytes, maintains its ability to differentiate into oligodendrocyte lineage cells efficiently throughout subsequent passages, and the cell expresses at least cell surface antigens CD133 and CD140[alpha]. The invention also provides a method of in vitro culturing an expandable neural progenitor or stem cell isolated from a mammalian central nervous system, and the culture itself,wherein the cell maintains its capability to differentiate into neurons, astrocytes, and oligodendrocytes and its ability to differentiate into oligodendrocyte-lineage cells efficiently. In addition,the invention provides a method of treating a condition caused by a loss of myelin or a loss of oligodendrocytes and a composition comprising an isolated expandable neural stem cell or one cultured bythe methods of the inventi
Bibliography:Application Number: CN201811129309