Method for removing isosalvianolic acid A1 and isosalvianolic acid A2 from sodium salvianolic acid A

• Main Authors: PAN YINGFENG, LUO QIAN, LING YIPING, LIU LI
• Format: Patent
• Language: Chinese; English
• Published: 14.05.2019
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a method for removing isosalvianolic acid A1 and isosalvianolic acid A2 from sodium salvianolic acid A. The method comprises the following steps: enabling a sodium salvianolicacid A raw material to be dissolved in water, and adding sodium chloride and mixing, refrigerating and placing in 0-10 DEG C, after separating out the sodium salvianolic acid A, filtering, washing byusing cold water in 0-10 DEG C and precipitating, drying a precipitate, to obtain the sodium salvianolic acid A of which content of the isosalvianolic acid A1 and the isosalvianolic acid A2 is reduced. The method is capable of further refining on the basis of the sodium salvianolic acid A, through salting out, greatly reducing the total content of two isomeride impurities of the isosalvianolic acid A1 and the isosalvianolic acid A2 in the sodium salvianolic acid A raw material, wherein a removal rate is up to 100%, thereby acquiring the controllable high-quality sodium salvianolic acid A withhigher purity (the purity a