Humanized liver animal model and construction method and application thereof

• Main Authors: LI HONGYAN, RAO XIURONG, HUANG YI, YI YANQIONG
• Format: Patent
• Language: Chinese; English
• Published: 10.05.2019
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

The invention relates to a humanized liver animal model and a construction method and application thereof. The construction method of the humanized liver animal model includes the following steps thathuman hepatic progenitor cells are injected into immunodeficient animals with the liver partially resected, and the humanized liver animal model is obtained. The construction method of the humanizedliver animal model is simple and convenient, and the problem is avoided that drugs harmful to the liver, viruses, bacteria and the like used in the construction process interfere with the applicationof the model in the later period. 本发明涉及一种人源化肝脏动物模型及其构建方法和应用。该人源化肝脏动物模型的构建方法包括以下步骤：将人源肝祖细胞注射入肝脏经部分切除的免疫缺陷动物中，得到人源化肝脏动物模型。经上述人源化肝脏动物模型的构建方法简捷，避免在构建过程中使用肝损伤药物、病毒、细菌等而给建模后期的应用带来干扰的问题。