Process for biosensor well formation

• Main Authors: DAVIS RANDALL W, LIU EDWARD SHIAN, HARADA ERIC TAKESHI, POLLARD JAMES, CECH CYNTHIA, TRANS ANDREW, AGUIRRE ANNE
• Format: Patent
• Language: Chinese; English
• Published: 10.05.2019
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to a process for biosensor well formation. Disclosed are a biochip for molecular detection and sensing. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate and having a density greater than 500 pores per square millimeter. Each discrete site includes a sidewall disposed on the substrate to form wells. Each discrete siteincludes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that crosstalk among the wells is reduced. In some embodiments, the electrodes disposed at thebottoms of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottoms of the wells has dedicated counter electrodes. In some embodiments, the surface of the sidewall is silylated such that the surface facilitates formation of the film in or near the wells. 本发明涉及用于生物传感器小孔形成的方法。公开了用于分子检测和感测的生物芯片。所述生物芯片包括衬底。