Composition and method for detecting purity of 1-amino-2-propanol and related substances

• Main Authors: SU ZHONGHAI, LYU QINGHUI, CHEN LILI
• Format: Patent
• Language: Chinese; English
• Published: 19.04.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

The invention provides a method for detecting the purity of 1-amino-2-propanol and related substances. The method is used for detecting the purity of 1-amino-2-propanol and the content of an isomer (2-amino-1-propanol). The purity of 1-amino-2-propanol and the related substances are qualitatively and/or quantitatively detected through a gas chromatography method, the known impurity (2-amino-1-propanol) is calculated through a standard curve method, other unknown impurities are calculated through an area normalization method, the total impurities are equal to the sum of the content of all the known impurities and the content of all the unknown individual impurities, and the purity of 1-amino-2-propanol is calculated through the difference of 100% and the total impurity content. The purity of 1-amino-2-propanol and the isomer impurity (2-amino-1-propanol) are detected. 本发明提供1-氨基-2-丙醇纯度及有关物质的检测方法，检测1-氨基-2-丙醇的纯度和异构体2-氨基-1-丙醇的含量。采用气相色谱法对1-氨基-2-丙醇的纯度以及有关物质进行定性和/或定量检测，其中已知杂质2-氨基-1-丙醇采用标准曲线法进行计算，其他未知杂质采用面积归化法进行计算，总杂＝