SWARM INTELLIGENCE-ENHANCED DIAGNOSIS AND THERAPY SELECTION FOR CANCER USING TUMOR- EDUCATED PLATELETS

• Main Authors: BEST MYRON GHISLAIN, WURDINGER THOMAS
• Format: Patent
• Language: Chinese; English
• Published: 16.04.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The invention provides methods of administering immunotherapy that modulates an interaction between PD-1 and its ligand, to a cancer patient, based on tumor-educated gene expression profiles obtainedfrom anucleated cells. The invention further provides methods of typing a sample of a subject for the presence or absence of a cancer, based on tumor-educated gene expression profiles obtained from anucleated cells. The invention further provides a method for obtaining a biomarker panel for typing of a sample from a subject using particle swarm optimization-based algorithms. 本发明提供了基于从无核细胞获得的经肿瘤教育的基因表达谱，对癌症患者施用调节PD-1及与其配体之间的相互作用的免疫疗法的方法。本发明进步提供了根据从无核细胞获得的经肿瘤教育的基因表达谱，归类受试者样品中存在或不存在癌症的方法。本发明进步提供了种用于获得生物标志物组的方法，所述生物标志物组用于使用基于粒子群优化的算法将来自受试者的样品归类。