Method for improving efficiency of killing retained bacteria by aminoglycoside antibiotics through low ion shock

• Main Authors: CHEN ZHONGYU, GAO YUANYUAN, FU XINMIAO
• Format: Patent
• Language: Chinese; English
• Published: 16.04.2019
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The invention discloses a method for improving the efficiency of killing retained bacteria by aminoglycoside antibiotics through low ion shock. The method comprises the following steps of: preparing antibiotics into an antibiotic pretreatment solution with a certain concentration by adopting an isotonic solution or a sterile aqueous solution, wherein the isotonic solution is a 0.3M glycerol solution or a 0.9% Nacl solution, and the sterile aqueous solution is double distilled water. The antibiotic pretreatment solution is used for carrying out resuspension treatment on bacterial liquid containing retained bacteria to be killed. The method can greatly improve the efficiency of killing the remained bacteria by the aminoglycoside antibiotics, effectively eliminate the retention of bacteria, reduce the tolerance of the bacteria, and reduce the dosage and the administration time on the premise of achieving the same treatment effect, thereby reducing the side effect of the antibiotics. 本发明公开了低离子休克提高氨基糖苷类抗生素杀灭持留菌效率的