18beta-glycyrrhetinic acid carbamate derivative, preparation method and application thereof

The invention discloses a 18beta-glycyrrhetinic acid carbamate derivative, which has a structure shown as formula (I) or (II) in the specification. The compound provided by the invention has a brand new structure, and has significant inhibitory effect on lung cancer, liver cancer, colon cancer, brea...

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Bibliographic Details
Main Authors CAI DONG, JIA YUNHONG, YANG DIANSHEN, GONG YIXIA, SUN YUQI
Format Patent
LanguageChinese
English
Published 12.04.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The invention discloses a 18beta-glycyrrhetinic acid carbamate derivative, which has a structure shown as formula (I) or (II) in the specification. The compound provided by the invention has a brand new structure, and has significant inhibitory effect on lung cancer, liver cancer, colon cancer, breast cancer and prostate cancer cell lines. And the antitumor activity of parts of the compounds is close to crizotinib. 本发明公开了种18β-甘草次酸氨基甲酸酯衍生物，具有如下式(Ⅰ)或式(Ⅱ)所示结构：本发明所述化合物结构全新，化合物对肺癌、肝癌、结肠癌、乳腺癌、前列腺癌细胞系具有显著的抑制作用；部分化合物抗肿瘤活性接近克唑替尼。
Bibliography:Application Number: CN201811581719