CircRNA related to MTX resistance of tumor cells and application of circRNA to reversal of MTX resistance of tumor cells

• Main Authors: MENG XIANGNING, WANG PING, GAO WEI, CAI MENGDI, ZHANG HUISHU, LYU YAFAN, ZHU JING, WANG XU, GUAN RONGWEI, HAN YUE, MA JINFA, SONG YING
• Format: Patent
• Language: Chinese; English
• Published: 09.04.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention discloses a circRNA related to MTX resistance of tumor cells and application of the circRNA to reversal of the MTX resistance of the tumor cells. An HT-29 MTX-sensitive and DMs-containing MTX-resistant cell line is selected as a study subject, the circRNA highly expressed in MTX-resist...