Application of 2,2-(4-carboxyl octanamide group)methyl benzoate to preparation of drugs for treating inflammatory diseases

• Main Authors: HU QINGHUA, LI HUANQIU, ZHOU MENGZE
• Format: Patent
• Language: Chinese; English
• Published: 05.04.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of 2,2-(4-carboxyl octanamide group)methyl benzoate or pharmaceutical salts thereof to preparation of drugs for treating inflammatory diseases. Compared with the prior art, the invention firstly discovers that the compound 2,2-(4-carboxyl octanamide group)methyl benzoate has a function of a P2Y14 receptor inhibitor, has an obvious effect of inhibiting inflammation related to a P2Y14 receptor, and can be used for preparing anti-inflammatory drugs acting on the P2Y14 receptor. 本发明公开了2,2-(4-羧基辛酰胺基)苯甲酸甲酯或其可药用的盐在制备治疗炎症性疾病药物中的应用。相对于现有技术，本发明首次发现了化合物2,2-(4-羧基辛酰胺基)苯甲酸甲酯具备P2Y受体抑制剂的功能，对P2Y受体相关炎症具有明显的抑制作用，可以用作制备作用于P2Y14受体的抗炎药物。