DRUG CONJUGATES WITH SELF-STABILIZING LINKERS HAVING IMPROVED PHYSIOCHEMICAL PROPERTIES

Compounds and compositions are disclosed in which a drug unit is linked to a targeting ligand unit through a self-stabilizing linker unit from which a drug compound or active drug moiety is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal...

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Bibliographic Details
Main Author MOQUIST PHILIP
Format Patent
LanguageChinese
English
Published 02.04.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds and compositions are disclosed in which a drug unit is linked to a targeting ligand unit through a self-stabilizing linker unit from which a drug compound or active drug moiety is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the inventionare also disclosed. 公开了化合物和组合物，其中药物单元通过自稳定性接头单元与靶向配体单元连接，从中释放出药物化合物或活性药物部分于被靶向的作用位点。还公开了使用本发明的化合物和组合物治疗以被靶向的异常细胞为特征的疾病的方法，所述疾病例如癌症或自身免疫疾病。
Bibliography:Application Number: CN20178047894