Hydrophobic nanogel and preparation method thereof

• Main Authors: ZHANG SONGHONG, YANG TINGTING, HUANG JIE, YUN JUNXIAN
• Format: Patent
• Language: Chinese; English
• Published: 29.03.2019
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; GENERAL PROCESSES OF COMPOUNDING; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The invention discloses a hydrophobic nanogel and a preparation method thereof. The hydrophobic nanogel adopts polyglycidyl methacrylate as a framework, has a particle size of 10-250 nm, a Zeta potential of -40 to -50 mV and a dispersion index of 0.1-0.2, and has a structure containing a hydrophobic glyceride group and a highly-active epoxy group structure, represented by formula (I), and each ofm and n in the formula (I) is an integer greater than zero. The novel hydrophobic nanogel has the dual characteristics of a hydrogel and a nanomaterial, has the advantages of small size, stable dispersion, uniform distribution and large specific surface area, and can be combined with other biochemical separation media to increase internal adsorption sites in the media in order to increase the adsorption amount; and the polyglycidyl methacrylate and other polymer materials with good biocompatibility are used, so the nanogel is highly safe. 本发明公开了种疏水性纳凝胶及其制备方法。所述的疏水性纳凝胶，以聚甲基丙烯酸缩水甘油酯为骨架，粒径为10～250 nm，Zeta电位为-40～-50 mV，分散指