Levofloxacin hydrochloride injection and preparation method thereof

• Main Authors: HU XIANDE, SUI RONGCHUN, LIAO NIANSHENG, ZOU MINGMING
• Format: Patent
• Language: Chinese; English
• Published: 29.03.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of injections, and discloses a levofloxacin hydrochloride injection and a preparation method thereof. The method comprises: stirring 3-10 parts by weight of polyethyleneimine, 6-10 parts by weight of an antioxidant and 2-5 parts by weight of an anti-photolysis agent with 300-400 parts by weight of water for injection for dissolving; adding 0.2-0.7 part by weightof medicinal carbon, and performing stirring and filtration; adding 20-50 parts by weight of levofloxacin hydrochloride and 400-500 parts by weight of water for injection, and performing stirring fordissolving; adjusting the pH value to 5.5-6.0; and adding injection water until the total weight is 1000 parts by weight, and carrying out membrane separation. The polyethyleneimine is added into theinjection, so that the content of the prepared medicine is higher than 99.9%, the stability is good within 6 months, the preparation process is simple, and the loss of metal elements in a patient bodyis avoided after ultrafiltr