Biomarkers for diagnosis of lung diseases and methods of use thereof

• Main Authors: KENNEDY GIULIA, VELICHKO SHARLENE, DIGGANS JAMES, WILDE JONATHAN, BARBACIORU CATALIN
• Format: Patent
• Language: Chinese; English
• Published: 22.03.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The present disclosure provides methods for diagnosis of interstitial lung diseases (ILDs). The present disclosure provides methods for differential diagnosis of idiopathic pulmonary fibrosis from other ILDs. Compositions and kits useful in carrying out a subject method are also provided. Interstitial Lung Disease (ILD), also known as diffuse parenchymal lung disease (DPLD), represent a variety ofdisorders that lead to diffuse remodeling, architectural damage to normal lung tissue and inflammation that lead to progressive loss of lung function. In addition to the inflammation and fibrosis that is often seen in the lung parenchyma in ILD, the airways and the vasculature may also be prominently affected. 本公开提供了用于诊断间质性肺疾病(ILD)的方法。本公开提供了区别诊断(differential diagonsis)特发性肺纤维化与其它ILD的方法。还提供了可用于执行主题方法的组合物和试剂盒。间质性肺疾病(ILD)，也被称作弥漫性实质性肺病(DPLD)，代表了多种病症，其可导致对正常肺组织的弥漫性重塑(diffuse remodeling)、结构损伤(architectural damage)和可导致肺功能进行性丧失的炎症。在ILD中，除了经常在肺实质中见到的炎症和纤维化之外，气管和脉管也会受到显著的影响。